Single Nucleotide Polymorphisms in Pediatric Idiopathic Nephrotic Syndrome
نویسندگان
چکیده
منابع مشابه
Examine of Thyroid Function in Pediatric Nephrotic Syndrome; Tehran-Iran
Introduction In children with nephrotic syndrome, it is probable to determine a hypothyroid state because of thyroxine (T4), tri-iodothyronine (T3) and thyroid-binding globulin loss in presence of proteinuria. Objectives: To examine thyroid function in pediatric cases of nephrotic syndrome. Methods: In a cross-sectional study, from march 2010 to march 2012, thyroid function tests were performed...
متن کاملImmunopathogenesis of idiopathic nephrotic syndrome.
Idiopathic nephrotic syndrome is the most frequent glomerular disease in children. The mechanisms underlying its pathophysiology have been investigated by genetic, cellular and molecular approaches. While genetic analyses have provided new insights into disease pathogenesis through the discovery of several podocyte genes mutated in distinct forms of inherited nephrotic syndrome, the molecular b...
متن کاملCytokine polymorphisms and nephrotic syndrome.
There is strong circumstantial evidence for a link between idiopathic childhood nephrotic syndrome, a clinical entity synonymous with the renal biopsy appearances of minimal change nephropathy (so-called because histological examination of the kidney in this condition shows no evidence of glomerular inflammation) and a disturbance of the cytokine balance in the immune system. In particular, the...
متن کاملSingle Nucleotide Polymorphisms and Association Studies: A Few Critical Points
Uncovering DNA sequence variations that correlate with phenotypic changes, e.g., diseases, is the aim of sequence variation studies. Common types sequence variations are Single nucleotide polymorphism (SNP, pronounced snip).SNPs are the third-generation molecular marker. SNP represents a DNA sequence variant of a single base pair with the minor allele occurring in more than 1% of a given popula...
متن کاملIdiopathic nephrotic syndrome in Iranian children.
Of 231 children with nephrotic syndrome, 87% were steroid sensitive and 13% steroid resistant. Of patients with steroid sensitive nephrotic syndrome, 38.8% were non-relapsers, 34.8% frequent relapsers and 26.4% infrequent relapsers. Among those with steroid resistant nephrotic syndrome, 37.5% had focal segmental glomerulosclerosis with a high mortality rate of 44%
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Nephrology
سال: 2016
ISSN: 2090-214X,2090-2158
DOI: 10.1155/2016/1417456